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KMID : 0613820210310060581
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Journal of Life Science
2021 Volume.31 No. 6 p.581 ~ p.586
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Evaluation of Anti-thrombosis Activities of Different Parts of Cannabis sativa L.
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Kang Deok-Gyeong
Kim Young-Min
Sohn Ho-Yong
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Abstract
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The high fatality of COVID-19 (Corona Virus Disease 2019) is closely related to acute pneumonia and severe blood clot formation in brain, heart, kidney and lung. The use of low-molecular weight heparins has been shown to reduce the risk of thrombosis and reduce fatality rates among COVID-19 patients. In this study, we investigated the antithrombotic activity of different parts of C. sativa extracts to determine its potential in preventing blood clots in patients with thromboprophylaxis. The extracts of leaf, stem, root, immature flower and seed of C. sativa showed strong inhibitory activities on blood clot formation. In particular, the flower extract showed the strongest inhibitions against blood coagulation factors and thrombin. Strong hemolysis activities were observed in flower extract and seed extract, suggested that removal of the hemolysis active compounds in th extracts is necessary. This is a first report of anti-thrombosis activities of different parts of C. sativa extracts, and our results suggest that C. sativa extract has potential has a valuable bioresource for high-value products.
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KEYWORD
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Anti-thrombosis, blood clot, Cannabis sativa L., coagulation factor, hemolysis
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